Frankly Speaking tells the melodrama story of Song Ki-baek, a 33-year-old announcer working for Ultra FM who develops a disorder that causes him to speak without thinking, and On Woo-ju, a variety show's writer who is willing to do anything for an entertaining program. Ki-baek's speaking action caused by his disorder catches the attention of Woo-ju who finds it interesting and decides to appear with him on a love variety show.