Kim Young-ae

Choi Gok-ji

Kang Mal-soon (cameo) – Hye-jung's grandmother.

Seo Tae-im, Chairwoman of Seungjin Group and Do-hyun's grandmother.

Go Soon-dong

Woo-jin's mother

Shin Hye-soo - The deputy director of the Gwang Hae University Hospital. She has been manipulating younger doctors, especially dr. Park, prof. Seo and chief Han, in order to have Royal Medical Centre opened. She is chairman's daughter in law (although divorced with his son). It's later revealed that she suffers from vascular dementia. Shin also had a son, who she gave up. Then the son died, before the two could reunite.

Lee Jung-ae

The Grand Royal Queen Dowager

Gong Soon-ho - The ruthless mother-in-law of Kim In-sook, and after her son's death takes custody of her grandson. She is a cold-hearted woman, even to her children, who believes cruelty is the only way she can teach them how to survive. However, she could never bear a betrayal from her own flesh and blood, and loves Hyun-jin whom she believes is coming into her own perfectly.

Hwa-young's mother

Im Baek-moo

Dr. Im Kyung-eun

Queen Myeongseong, Sukjong's mother

Yeol-sun

Dong-hoon's mother

Jung Jin-sook (Jae-ho's aunt)

Hong Young-sook, Agency for National Security Planning and Consul General to Russia, aunt of Jung-yeon

Sun-bi No